(a) tamamen ayrılmış, ilgisini kesmiş, kaybolmuş.
My son was lost to me when he married. (b) kapanmış, olasılıksız, elinden çıkmış.
The chance of promotion was lost to him. (c) duygusuz, hissiz, vurdumduymaz.
He was lost to all sense of duty.
to be lost to all sense of shame: utanç duygusu kalmamak, ar damarı çatlamak.